1-Bromo-2-nitrobenzene

CAS NO.：577-19-5
Empirical Formula: C6H4BrNO2
Molecular Weight: 202.01
MDL number: MFCD00007045
EINECS: 209-409-0
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:58:17

What is 1-Bromo-2-nitrobenzene?

Chemical properties

white to light yellow crystal powder

The Uses of 1-Bromo-2-nitrobenzene

1-Bromo-2-nitrobenzene is used in organic synthesis. It also can react with 2-methylamino-benzoic acid to get N-methyl-N-(2-nitro-phenyl)-anthranilic acid. And it is also used in the preparation of 4-methoxy-2?-nitrodiphenyl ether, 1-methoxy-3,5-bis-(2-nitro-phenoxy)benzene.

The Uses of 1-Bromo-2-nitrobenzene

1-Bromo-2-nitrobenzene may be used in the preparation of:

4-methoxy-2′-nitrodiphenyl ether
1-methoxy-3,5-bis-(2-nitro-phenoxy)benzene
5-hydroxy-3-methoxy-2′-nitrodiphenyl ether

General Description

1-Bromo-2-nitrobenzene undergoes palladium[0]-mediated Ullmann cross-coupling reaction with a range of β-halo-enals, -enones or -esters to afford the corresponding β-aryl derivatives. Palladium[0]-mediated Ullmann cross-coupling reaction of 1-bromo-2-nitrobenzene with β-bromo-α,β-unsaturated aldehydes is reported.

Purification Methods

Crystallise it twice from pet ether, using charcoal before the first crystallisation. [Beilstein 5 III 618, 5 IV 728.]

Properties of 1-Bromo-2-nitrobenzene

Melting point:	40-42 °C (lit.)
Boiling point:	261 °C (lit.)
Density	1.7 g/cm3 (20℃)
refractive index	1.6060 (estimate)
Flash point:	>230 °F
storage temp.	2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	powder to crystal
color	Light yellow to Amber to Dark green
Water Solubility	insoluble
BRN	2044109
Stability:	Stable. Combustible. Incompatible with strong bases, strong oxidizing agents.
CAS DataBase Reference	577-19-5(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 1-bromo-2-nitro-(577-19-5)
EPA Substance Registry System	o-Bromonitrobenzene (577-19-5)

Safety information for 1-Bromo-2-nitrobenzene

Signal word	Warning
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H302:Acute toxicity,oral H312:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H331:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H373:Specific target organ toxicity, repeated exposure
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..…