1-BROMO-1-PROPENE

Chemical properties

CLEAR COLOURLESS TO LIGHT YELLOW LIQUID

The Uses of 1-BROMO-1-PROPENE

1-Bromo-1-propene upon n-BuLi treatment generates the propynyllithium anion, in situ, which later undergoes nucleophilic addition reactions. Some of its other applications are:

• Synthesis of organic reagents such as methyl but-2-ynoate and 1-iodopropyne.
• Preparation o f intermediates in the total synthesis of (+)-aphanamol I and skyllamycins A-C.
• Synthesis of allylated pyrazoles, aryl alkynyl sulfides and allenamides.

The Uses of 1-BROMO-1-PROPENE

1-Propenyl bromide is a useful building block, especially when a 3 carbon addition is required, such as its use in the synthesis of the pharmaceutical spilanthol.

Synthesis Reference(s)

The Journal of Organic Chemistry, 56, p. 4066, 1991 DOI: 10.1021/jo00012a053