1-Boc-Pyrrolidine
Synonym(s):tert-Butyl 1-pyrrolidinecarboxylate
- CAS NO.：86953-79-9
- Empirical Formula: C9H17NO2
- Molecular Weight: 171.24
- MDL number: MFCD00216581
- EINECS: 617-940-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 05:38:27
What is 1-Boc-Pyrrolidine?
Chemical properties
liquid
The Uses of 1-Boc-Pyrrolidine
1-Boc-pyrrolidine is a boc-protected cyclic amine used as a building block in the preparation of diastereomers by usually undergoing α'-lithiations and electrophilic substitution reactions.
The Uses of 1-Boc-Pyrrolidine
N-Boc-pyrrolidine may be used in the synthesis of the following:
- 2-aryl-N-boc-pyrrolidines
- scalemic 2-pyrrolidinylcuprates
- 2-alkenyl-N-Boc-pyrrolidines
- 1-deoxycastanospermine
- methylphenidate analogues
- (+)-elaeokanine A
General Description
N-Boc-pyrrolidine is an N-substituted pyrrolidine. It is reported that the reactivity of N-Boc-pyrrolidine towards C-H insertion reaction is 2000 times more than cyclohexane. It undergoes α-arylation in the presence of a palladium catalyst with high enantioselectivity.
Properties of 1-Boc-Pyrrolidine
| Boiling point: | 80 °C/0.2 mmHg (lit.) |
| Density | 0.977 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 187 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform, Methanol |
| form | Oil |
| pka | -1.28±0.20(Predicted) |
| color | Clear Colorless |
| BRN | 4664750 |
| CAS DataBase Reference | 86953-79-9(CAS DataBase Reference) |
Safety information for 1-Boc-Pyrrolidine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-Boc-Pyrrolidine
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