1-(2-Amino-5-hydroxyphenyl)propan-1-one
- CAS NO.：35364-15-9
- Empirical Formula: C9H11NO2
- Molecular Weight: 165.19
- MDL number: MFCD16877176
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 1-(2-Amino-5-hydroxyphenyl)propan-1-one?
The Uses of 1-(2-Amino-5-hydroxyphenyl)propan-1-one
1-(2-Amino-5-hydroxyphenyl)propan-1-one is a useful synthetic intermediate. It is used in the asymmetrical synthesis of (S)-4-ethyl-6,7,8,10- tetrahydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione, a key intermediate for synthesis of irinotecan and other camptothecin analogs. It is also used in the synthesis of E-?ring-?modified (RS)?-?camptothecin analogs as antitumor agents.
Preparation
Obtained by UV-irradiation of 3-ethyl-2,1-benzisoxazole in 66% sulfuric acid for 90 min at 80–90°
Also prepared from 2-nitro-5-hydroxybenzaldehyde (five steps) or from p-anisidine.
Properties of 1-(2-Amino-5-hydroxyphenyl)propan-1-one
| Melting point: | 144.5-144.9 °C |
| Boiling point: | 363.9±32.0 °C(Predicted) |
| Density | 1.195±0.06 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9.35±0.18(Predicted) |
| color | Light Yellow to Brown |
| Stability: | Hygroscopic |
Safety information for 1-(2-Amino-5-hydroxyphenyl)propan-1-one
Computed Descriptors for 1-(2-Amino-5-hydroxyphenyl)propan-1-one
1-(2-Amino-5-hydroxyphenyl)propan-1-one manufacturer
OCIMUM LIFESCIENCES PVT LTD
3Y
Phone:+91-8891777669
Whatsapp: +91- 8891777669
product: 35364-15-9 97%
ALS India Life Sciences Pvt. Ltd
3Y
Phone:+91-8977036378
Whatsapp: +91 8008166674
product: 1-(2-Amino-5-hydroxyphenyl)propan-1-one 99.96%
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