(+/-)-trans-1,2-Diaminocyclohexane

Synonym(s):(±)-trans-1,2-Cyclohexanediamine

CAS NO.：1121-22-8
Empirical Formula: C6H14N2
Molecular Weight: 114.19
MDL number: MFCD00063747
EINECS: 601-163-6
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-27 17:24:33

(+/-)-trans-1,2-Diaminocyclohexane Structural

What is (+/-)-trans-1,2-Diaminocyclohexane?

Chemical properties

clear colorless to light yellow liquid

The Uses of (+/-)-trans-1,2-Diaminocyclohexane

(^+)-trans-1,2-Diaminocyclohexane is employed in the synthesis of macrocyclic [3+3] hexa Schiff base. It also plays an important role in the preparation of multidentate ligands, chiral auxiliaries and chiral stationary phases. Further, it is used to prepare [2+2] macrocyclization by reacting with aliphatic dialdehydes. In addition to this, it acts as a chiral ligand, which finds application in asymmetric catalysis.

The Uses of (+/-)-trans-1,2-Diaminocyclohexane

(±)-trans-1,2-Diaminocyclohexane was used in the synthesis of macrocyclic [3+3] hexa Schiff base. It was also employed in the synthesis of multidentate ligands, chiral auxiliaries and chiral stationary phases.

What are the applications of Application

(±)-trans-1,2-Diaminocyclohexane is a reagent used in the synthesis of multidentate ligands, chiral auxiliaries, and chiral stationary phases

General Description

(±)-trans-1,2-Diaminocyclohexane was condensed with aliphatic dialdehydes to form [3+3] or [2+2] macrocyclization products.

Purification Methods

Purify and store the diamine as for the cis-isomer above as it is a strong base and becomes yellow on storage. [Beilstein 13 IV 1.]

Properties of (+/-)-trans-1,2-Diaminocyclohexane

Melting point:	14-15 °C(lit.)
Boiling point:	79-81 °C15 mm Hg(lit.)
Density	0.951 g/mL at 25 °C(lit.)
vapor pressure	0.4 mm Hg ( 20 °C)
refractive index	n20/D 1.489(lit.)
Flash point:	156 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	9.94(at 20℃)
form	Liquid
color	Clear colorless to light yellow
Water Solubility	Soluble
Sensitive	Air Sensitive
BRN	506142
CAS DataBase Reference	1121-22-8(CAS DataBase Reference)
NIST Chemistry Reference	trans-1,2-Cyclohexanediamine(1121-22-8)
EPA Substance Registry System	1,2-Cyclohexanediamine, (1R,2R)-rel- (1121-22-8)

Safety information for (+/-)-trans-1,2-Diaminocyclohexane

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.