CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Melting Point | 168 |
| Solubility | White or creamy white, small crystals or crystalline powder; characteristic, mildly aromatic odor; 1 g sol in: about 0.6 mL water, about 0.6 ml chloroform, 1 ml absolute methanol, 1 ml alcohol; practically insoluble in ether /Diethylpropion hydrochloride/ |
| LogP | 2.8 |
| Stability/Shelf Life | Stable in dry air /Diethylpropion hydrochloride/ |
| Decomposition | When heated to decomp it emits very toxic fumes of /hydrogen chloride and nitrogen oxides./ /Diethylpropion hydrochloride/ |
| Collision Cross Section | 148 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)] |
| Kovats Retention Index | 1483 1470 1495 1476 1489 1490 1480 1492.6 1493.1 1490.9 1499.4 1470 1480 1483 1470 1465 1475 1486 1485 |
| Other Experimental Properties | Crystals; dec 168 °C /Hydrochloride/ |
COMPUTED DESCRIPTORS
| Molecular Weight | 205.30 g/mol |
|---|---|
| XLogP3 | 2.8 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 5 |
| Exact Mass | 205.146664230 g/mol |
| Monoisotopic Mass | 205.146664230 g/mol |
| Topological Polar Surface Area | 20.3 Ų |
| Heavy Atom Count | 15 |
| Formal Charge | 0 |
| Complexity | 193 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Diethylpropion is an aromatic ketone that is propiophenone in which one of the hydrogens alpha- to the carbonyl is substituted by a diethylamino group. A central stimulant and indirect-acting sympathomimetic, it is an appetite depressant and is used as the hydrochloride as an anoretic in the short term management of obesity. It has a role as an appetite depressant. It is a tertiary amine and an aromatic ketone. It is functionally related to a propiophenone.