846-49-1
Product Name:
Lorazepam
Formula:
C15H10Cl2N2O2
Synonyms:
(±)-Lorazepam;7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Boiling Point | 533.8 ºC at 760 mm Hg |
| Melting Point | 192-194 |
| Solubility | 80 mg/L |
| LogP | 2.39 |
| LogS | -3.6 |
| Caco2 Permeability | 200 |
| Dissociation Constants | 13 |
| Collision Cross Section | 165.8 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)] |
| Kovats Retention Index | 2426 2375 2375 2380 2423 2423 2448 2384 2430 2399 2411 2442 2430 2440 2402 2402 2448 2410 2403.2 2391 2430 2395 2402 2415.3 |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Health Hazard GHS08 |
| GHS Hazard Statements |
H361:Reproductive toxicity |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..… |
COMPUTED DESCRIPTORS
| Molecular Weight | 321.2 g/mol |
|---|---|
| XLogP3 | 2.4 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 1 |
| Exact Mass | 320.0119330 g/mol |
| Monoisotopic Mass | 320.0119330 g/mol |
| Topological Polar Surface Area | 61.7 Ų |
| Heavy Atom Count | 21 |
| Formal Charge | 0 |
| Complexity | 443 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Lorazepam is a benzodiazepine.