83730-53-4
Product Name:
L-BUTHIONINE-(S,R)-SULFOXIMINE
Formula:
C8H18N2O3S
Synonyms:
L- Buthionine Sulfoximine - CAS 83730-53-4 - Calbiochem;L-BSO
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | White crystalline solid; [Sigma-Aldrich MSDS] |
|---|---|
| Solubility | H2O > 100 (mg/mL) |
| Stability/Shelf Life | Bulk: Samples subjected to both light and dark conditions at room temperature showed no decomposition after 90 days. Samples kept at 50 °C in both light and dark conditions showed about 1% decomposition after 90 days. Solution: BSO was found to be stable in aqueous solution for 72 hours when stored at room temperature and under laboratory light. |
| Optical Rotation | (c = 1, 1 N HC1) [a]20D = +32.5 ± 2° |
| Collision Cross Section | 146.1 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards] |
| Chemical Classes | Other Uses -> Biochemical Research |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
COMPUTED DESCRIPTORS
| Molecular Weight | 222.31 g/mol |
|---|---|
| XLogP3 | -0.6 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 7 |
| Exact Mass | 222.10381361 g/mol |
| Monoisotopic Mass | 222.10381361 g/mol |
| Topological Polar Surface Area | 113 Ų |
| Heavy Atom Count | 14 |
| Formal Charge | 0 |
| Complexity | 284 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
L-buthionine-(S,R)-sulfoximine is a 2-amino-4-(S-butylsulfonimidoyl)butanoic acid which has S-configuration. It is a inhibitor of gamma-glutamylcysteine synthetase and glutathione (GSH) biosynthesis and is capable of enhancing the apoptotic effects of several chemotherapeutic agents. It has a role as a ferroptosis inducer and an EC 6.3.2.2 (glutamate--cysteine ligase) inhibitor.