COMPUTED DESCRIPTORS
| Molecular Weight | 2529.5 g/mol |
|---|---|
| Hydrogen Bond Donor Count | 28 |
| Hydrogen Bond Acceptor Count | 30 |
| Rotatable Bond Count | 93 |
| Exact Mass | 2528.8548875 g/mol |
| Monoisotopic Mass | 2527.8515327 g/mol |
| Topological Polar Surface Area | 813 Ų |
| Heavy Atom Count | 178 |
| Formal Charge | 0 |
| Complexity | 4910 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 21 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 2 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Lucinactant is a new synthetic peptide-containing surfactant for intratracheal use. It contains sinapultide, a novel, hydrophobic, 21-amino acid peptide (leucine and lysine repeating units, KL4 peptide) designed to mimic human surfactant protein-B (SB-P). More specifically, it mimics the C-terminal amphipathic helical domain of this protein. It also consists of phospholipids (dipalmitoylphosphatidylcholine, DPPC and palmitoyloleoyl phosphatidylglycerol, POPG) and a fatty acid (palmitic acid). It is completely devoid of animal-derived components. FDA approved on March 6, 2012.