8068-37-9
Product Name:
COLISTIMETHATE SODIUM
Formula:
C58H105N16Na5O28S5
Synonyms:
Colistimethate sodium;CMS;Colistin sodium methanesulfonate;Colistin sulphomethate sodium;Methanesulfonic acid derivative of Polymyxin E
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COMPUTED DESCRIPTORS
| Molecular Weight | 1749.8 g/mol |
|---|---|
| Hydrogen Bond Donor Count | 18 |
| Hydrogen Bond Acceptor Count | 33 |
| Rotatable Bond Count | 39 |
| Exact Mass | 1748.5376240 g/mol |
| Monoisotopic Mass | 1748.5376240 g/mol |
| Topological Polar Surface Area | 749 Ų |
| Heavy Atom Count | 112 |
| Formal Charge | 0 |
| Complexity | 3430 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 13 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 6 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Colistimethate is a broad-spectrum polymyxin antibiotic against most aerobic Gram-negative bacteria except Proteus bacteria. Colistimethate is a mixture of methanesulfonate derivatives of cyclic polypeptides colistin A and B from Bacillus colistinus or B. polymyxa. Colistin functions as a surfactant which penetrates into and disrupts the bacterial cell membrane, thereby resulting in bactericidal effect.