CHEMICAL AND PHYSICAL PROPERTIES
| Color/Form | White solid from cyclohexane |
|---|---|
| Melting Point | 68.5-69 °C |
| Optical Rotation | Specific optical rotation: +161.4 deg at 20 °C/589 ( c = 0.038 g/2 ml ethanol) |
| Other Experimental Properties | MW: 337.37. Crystalline solid; MP: 208.5-210 °C; Specific optical rotation: +114 deg at 20 °C/D ( c = 0.0128 g/2 ml ethanol) /Maleate/ |
COMPUTED DESCRIPTORS
| Molecular Weight | 221.30 g/mol |
|---|---|
| XLogP3 | 2.8 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 221.120449483 g/mol |
| Monoisotopic Mass | 221.120449483 g/mol |
| Topological Polar Surface Area | 12 Ų |
| Heavy Atom Count | 17 |
| Formal Charge | 0 |
| Complexity | 313 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Dizocilpine is an organic heterotetracyclic compound that is 1-methyl-8-azabicyclo[3.2.1]octane ortho-fused to two benzene rings at positions 2-3 and 6-7 (the 5S,10R-stereoisomer). It is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor and affects cognitive function, learning, and memory. It has a role as a NMDA receptor antagonist, an anaesthetic, an anticonvulsant, a nicotinic antagonist and a neuroprotective agent. It is a secondary amino compound and a tetracyclic antidepressant. It is a conjugate base of a dizocilpine(1+).