CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Melting Point | 223 °C |
| Solubility | 1420 mg/L |
| Vapor Pressure | 8.4X10-7 mm Hg @ 25 °C /Estimated/ |
| LogP | 0.06 |
| Henry's Law Constant | Henry's Law constant = 8.9X10-15 atm-cu m/mole @ 25 °C /Estimated/ |
| Stability/Shelf Life | Procarbazine hydrochloride is unstable in aqueous solution. /Procarbazine hydrochloride/ |
| Dissociation Constants | pKa = 6.6 |
| Kovats Retention Index | 1990 1975 2000 1990 |
| Other Experimental Properties | MW: 257.77. Crystals from methanol, mp 223-226 °C. /Hydrochloride/ |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H351:Carcinogenicity H361:Reproductive toxicity |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
COMPUTED DESCRIPTORS
| Molecular Weight | 221.30 g/mol |
|---|---|
| XLogP3 | 0.1 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 5 |
| Exact Mass | 221.152812238 g/mol |
| Monoisotopic Mass | 221.152812238 g/mol |
| Topological Polar Surface Area | 53.2 Ų |
| Heavy Atom Count | 16 |
| Formal Charge | 0 |
| Complexity | 210 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Procarbazine is a benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands. It has a role as an antineoplastic agent. It is a member of hydrazines and a member of benzamides. It is a conjugate base of a procarbazine(1+).