65988-71-8
Product Name:
GD2-GANGLIOSIDE
Formula:
C74H134N4O32
Synonyms:
GalNAcβ1,4(Neu5Acα2,8)(Neu5Acα2,03)Galβ1,4Glcβ1,1ʹ Ceramide;Ganglioside GD₂, Disialo, Human Brain - CAS 65988-71-8 - Calbiochem
Inquiry
COMPUTED DESCRIPTORS
| Molecular Weight | 1591.9 g/mol |
|---|---|
| XLogP3 | -1.9 |
| Hydrogen Bond Donor Count | 22 |
| Hydrogen Bond Acceptor Count | 34 |
| Rotatable Bond Count | 54 |
| Exact Mass | 1590.8981181 g/mol |
| Monoisotopic Mass | 1590.8981181 g/mol |
| Topological Polar Surface Area | 601 Ų |
| Heavy Atom Count | 110 |
| Formal Charge | 0 |
| Complexity | 2620 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 23 |
| Undefined Atom Stereocenter Count | 6 |
| Defined Bond Stereocenter Count | 1 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Ganglioside GD2 is a cell surface antigen expressed on all tumors of neuroectodermal origin, including melanoma, neuroblastomas, sarcoma, astrocytomas, and small cell lung cancer. GD2, an O-acetylated disialoganglioside, belongs to the group of glycosphingolipids that are widely expressed in many tissues and organs in vertebrates and have been suggested to be involved in the regulation of development and differentiation as recognition molecules or signal modulators. Due to its high level of expression in neuroblastoma, GD2 has the potential to be used as a component of anti-neuroblastoma vaccines, in addition to being used in polyvalent anti-melanoma vaccines.