65141-46-0
Product Name:
Nicorandil
Formula:
C8H9N3O4
Synonyms:
2-(Pyridine-3-carbonylamino)ethyl nitrate;2-Nicotinamidoethyl nitrate;Ikorel;N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide;SG-75
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Melting Point | 92-93 |
|---|---|
| Solubility | Partly miscible |
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H242:Self-reactive substances and mixtures; and Organic peroxides H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P235:Keep cool. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P370+P378:In case of fire: Use … for extinction. P410:Protect from sunlight. |
COMPUTED DESCRIPTORS
| Molecular Weight | 211.17 g/mol |
|---|---|
| XLogP3 | 0.8 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 4 |
| Exact Mass | 211.05930578 g/mol |
| Monoisotopic Mass | 211.05930578 g/mol |
| Topological Polar Surface Area | 97 Ų |
| Heavy Atom Count | 15 |
| Formal Charge | 0 |
| Complexity | 228 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Nicorandil is a pyrimidinecarboxamide that is nicotinamide in which one of the hydrogens attached to the carboxamide nitrogen is replaced by a 2-(nitrooxy)ethyl group. It has both nitrate-like and ATP-sensitive potassium channel activator properties, and is used for the prevention and treatment of angina pectoris. It has a role as a vasodilator agent and a potassium channel opener. It is a pyridinecarboxamide and a nitrate ester. It is functionally related to a nicotinamide.