637-07-0
Product Name:
Clofibrate
Formula:
C12H15ClO3
Synonyms:
2-(4-Chlorophenoxy)-2-methylpropionic acid ethyl ester;Ethyl 2-(4-chlorophenoxy)-2-methylpropionate;Ethyl 2-(4-chlorophenoxy)isobutyrate
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Color/Form | OIL |
| Odor | FAINT CHARACTERISTIC ODOR |
| Taste | FAINT CHARACTERISTIC TASTE |
| Boiling Point | 149 °C at 2.00E+01 mm Hg |
| Melting Point | 118-119 |
| Solubility | Insoluble |
| Density | 1.138-1.144 @ 20 °C |
| LogP | 3.3 |
| Stability/Shelf Life | SENSITIVE TO OXIDATION AND LIGHT; EASILY HYDROLYZED |
| Refractive Index | INDEX OF REFRACTION: 1.500-1.505 @ 19.5-20.5 °C/D; MAX ABSORPTION (DEHYDRATED ETHANOL): 226 NM (A= 910, 1%, 1 CM); 280 NM (A= 87, 1%, 1 CM); 288 NM (A= 62, 1%, 1 CM) |
| Kovats Retention Index | 1535.1 1524 1549 1515 1549 |
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
COMPUTED DESCRIPTORS
| Molecular Weight | 242.70 g/mol |
|---|---|
| XLogP3 | 3.3 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 5 |
| Exact Mass | 242.0709720 g/mol |
| Monoisotopic Mass | 242.0709720 g/mol |
| Topological Polar Surface Area | 35.5 Ų |
| Heavy Atom Count | 16 |
| Formal Charge | 0 |
| Complexity | 232 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Clofibrate is the ethyl ester of clofibric acid. It has a role as an anticholesteremic drug, an antilipemic drug, a geroprotector and a PPARalpha agonist. It is an aromatic ether, a member of monochlorobenzenes and an ethyl ester. It is functionally related to a clofibric acid.