CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Color/Form | Oily liq |
| Odor | Amine odor |
| Boiling Point | 203-210 °C at 3.00E-01 mm Hg |
| Melting Point | < 25 °C |
| Solubility | 14.2 mg/L (at 24 °C) |
| LogP | 4.55 |
| LogS | -4.3 |
| Stability/Shelf Life | Promazine HCl is maximally stable at pH 6.5 /Promazine HCl/ |
| Decomposition | When heated to decomposition it emits very toxic fumes of nitroxides and sulfoxides. |
| pH | Alkaline reaction |
| Dissociation Constants | 9.28 |
| Collision Cross Section | 161.5 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)] |
| Kovats Retention Index | 2329 2304.5 2315 2327 2367 2326 2310 2316 2342.2 2318.8 2325.1 2325.1 2313 2330 2335 2316 2338.9 |
| Other Experimental Properties | Decomp at 181 °C (microblock); Hygroscopic; Aq soln are slightly acid to litmus /Hydrochloride/ |
COMPUTED DESCRIPTORS
| Molecular Weight | 284.4 g/mol |
|---|---|
| XLogP3 | 4.5 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 4 |
| Exact Mass | 284.13471982 g/mol |
| Monoisotopic Mass | 284.13471982 g/mol |
| Topological Polar Surface Area | 31.8 Ų |
| Heavy Atom Count | 20 |
| Formal Charge | 0 |
| Complexity | 285 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Promazine is a phenothiazine deriative in which the phenothiazine tricycle has a 3-(dimethylaminopropyl) group at the N-10 position. It has a role as a dopaminergic antagonist, a H1-receptor antagonist, a muscarinic antagonist, a serotonergic antagonist, a phenothiazine antipsychotic drug, an antiemetic and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor. It is a member of phenothiazines and a tertiary amine.