CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Color/Form | Oily product |
| Melting Point | Crystals from ethyl acetate; MP: 115-120 °C /tartrate/ |
| Solubility | WHITE TO PALE YELLOW CRYSTALLINE POWDER; FAINT ODOR; DECOMP @ ABOUT 178 °C; 1 G SOL IN 20 ML WATER, ABOUT 30 ML ALC, IN 8 ML CHLOROFORM, ABOUT 6.6 ML METHANOL /BESYLATE/ |
| LogP | 3.9 |
| Stability/Shelf Life | STABLE IN SOLN OF PH 4.0-6.5; SOLN ARE LIGHT-SENSITIVE /BESYLATE/ |
| Decomposition | When heated to decomposition it emits very toxic fumes of sulfoxides and nitroxides. |
| Dissociation Constants | 9.61 |
| Kovats Retention Index | 3326 3319.2 3326 |
| Other Experimental Properties | INJECTION HAS PH OF 4.0-5.0 /BESYLATE/ |
COMPUTED DESCRIPTORS
| Molecular Weight | 386.6 g/mol |
|---|---|
| XLogP3 | 4.5 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 4 |
| Exact Mass | 386.14865580 g/mol |
| Monoisotopic Mass | 386.14865580 g/mol |
| Topological Polar Surface Area | 68.1 Ų |
| Heavy Atom Count | 26 |
| Formal Charge | 0 |
| Complexity | 502 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 2 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Mesoridazine is a phenothiazine substituted at position 2 (para to the S atom) by a methylsulfinyl group, and on the nitrogen by a 2-(1-methylpiperidin-2-yl)ethyl group. It has a role as a dopaminergic antagonist and a first generation antipsychotic. It is a member of phenothiazines, a sulfoxide and a tertiary amino compound.