52-67-5
Product Name:
D-Penicillamine
Formula:
C5H11NO2S
Synonyms:
D- (−)-2-Amino-3-mercapto-3-methylbutanoic acid;D -Penicillamine;3,3-Dimethyl-D -cysteine;3-Mercapto-D -valine
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Color/Form | FINE, WHITE OR PRACTICALLY WHITE, CRYSTALLINE POWDER |
|---|---|
| Odor | SLIGHT CHARACTERISTIC ODOR |
| Taste | SLIGHTLY BITTER |
| Melting Point | 198.5 °C |
| Solubility | 111000 mg/L (at 20 °C) |
| LogP | -1.78 |
| LogS | -0.13 |
| Stability/Shelf Life | RELATIVELY STABLE IN BOTH LIGHT & AIR. |
| Optical Rotation | SPECIFIC OPTICAL ROTATION: -63 DEG @ 25 °C/D (CONCENTRATION BY VOLUME = 0.1 G IN 100 ML PYRIDINE) |
| Decomposition | When heated to decomposition it emits very toxic fumes of oxides of nitrogen and oxides of sulfur. |
| Dissociation Constants | 7.83 |
| Other Experimental Properties | CRYSTALS; DECOMP 201 °C; PK VALUES: CARBOXYL 1.8, ALPHA-AMINO 7.9, BETA-THIOL 10.5 /DL-PENICILLAMINE/ |
| Chemical Classes | Other Uses -> Pharmaceuticals |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Health Hazard GHS08 |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..… |
COMPUTED DESCRIPTORS
| Molecular Weight | 149.21 g/mol |
|---|---|
| XLogP3 | -1.8 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 2 |
| Exact Mass | 149.05104977 g/mol |
| Monoisotopic Mass | 149.05104977 g/mol |
| Topological Polar Surface Area | 64.3 Ų |
| Heavy Atom Count | 9 |
| Formal Charge | 0 |
| Complexity | 124 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
D-penicillamine is an optically active form of penicillamine having D-configuration. Pharmaceutical form (L-form is toxic) of chelating agent used to treat heavy metal poisoning. It has a role as a chelator, an antirheumatic drug, a drug allergen and a copper chelator. It is a penicillamine and a non-proteinogenic alpha-amino acid. It is an enantiomer of a L-penicillamine.