50-76-0
Product Name:
Actinomycin D
Formula:
C62H86N12O16
Synonyms:
Dactinomycin;Actinomycin D;Actinomycin D solution from Streptomyces sp.;Actinomycin D, Streptomyces sp. - CAS 50-76-0 - Calbiochem;Actinomycin IV
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Actinomycin d appears as bright red rhomboid prisms or red powder. (NTP, 1992) |
|---|---|
| Color/Form | Bright red crystalline powder |
| Melting Point | 467 to 469 °F (decomposes) (NTP, 1992) |
| Solubility | Soluble at 50 °F (NTP, 1992) |
| LogP | 1.6 |
| Stability/Shelf Life | Dilute soln are very sensitive to light /Trihydrate/ |
| Decomposition | When heated to decomposition it emits toxic fumes of /nitrogen oxides/. |
| Dissociation Constants | pKa = 11.90 |
| Collision Cross Section | 341.2 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards] |
| Other Experimental Properties | Bright red, rhomboid prisms from abs alcohol; decomposes at 241.5-243 °C; specific optical rotation: -315 deg at 28 °C/D (c = 0.25 in methanol); absorption max (methanol): 244, 441 nm; dilute solutions are very sensitive to light; soluble in alcohol, propylene glycol, water and glycol mixtures. /Trihydrate/ |
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H300:Acute toxicity,oral H350:Carcinogenicity |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
COMPUTED DESCRIPTORS
| Molecular Weight | 1255.4 g/mol |
|---|---|
| XLogP3 | 3.8 |
| Hydrogen Bond Donor Count | 5 |
| Hydrogen Bond Acceptor Count | 18 |
| Rotatable Bond Count | 8 |
| Exact Mass | 1254.62847470 g/mol |
| Monoisotopic Mass | 1254.62847470 g/mol |
| Topological Polar Surface Area | 356 Ų |
| Heavy Atom Count | 90 |
| Formal Charge | 0 |
| Complexity | 3030 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 10 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Actinomycin d appears as bright red rhomboid prisms or red powder. (NTP, 1992)