37577-28-9
Product Name:
D-(+)-Norephedrine
Formula:
C9H13NO
Synonyms:
(1S,2R)-2-Amino-1-phenyl-1-propanol;erythro-α-(1-aminoethyl)benzyl alcohol;D -(+)-Norephedrine;Phenylpropanolamine
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Color/Form | White, crystalline powder |
| Odor | Slight aromatic odor |
| Melting Point | 101-101.5 °C |
| Solubility | Freely soluble in water and alcohol |
| LogP | log Kow = 0.67 |
| Decomposition | When heated to decomposition it emits very toxic fumes of nitroxides. |
| Dissociation Constants | 9.05 |
| Collision Cross Section | 127.8 Ų [M+H-H2O]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards] |
| Other Experimental Properties | Crystals; melting point 190-194 °C; odor resembling that of crude benzoic acid; pKa 9.44 + or - 0.04. Freely soluble in water, alcohol; practically insoluble in ether, chloroform, benzene. The aq soln is neutral to litmus. /Phenylpropanolamine hydrochloride/ |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
COMPUTED DESCRIPTORS
| Molecular Weight | 151.21 g/mol |
|---|---|
| XLogP3 | 0.8 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 2 |
| Exact Mass | 151.099714038 g/mol |
| Monoisotopic Mass | 151.099714038 g/mol |
| Topological Polar Surface Area | 46.2 Ų |
| Heavy Atom Count | 11 |
| Formal Charge | 0 |
| Complexity | 110 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
(+)-norephedrine is an amphetamine that is propylbenzene substituted by a hydroxy group at position 1 and by an amino group at position 2 (the 1S,2R-stereoisomer). It is a member of amphetamines and a phenethylamine alkaloid.