3223-07-2
Product Name:
4-BIS(2-CHLORETHYL)-AMINO-L-PHENYLALANINE HYDROCHLORIDE
Formula:
C13H19Cl3N2O2
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Solubility | 95% ethanol <0.9 (mg/mL) |
|---|---|
| Stability/Shelf Life | Bulk: A dried sample, stored at 60 °C for 15 days, showed about 10% decomposition as indicated by UV absorption and ionic chloride content. Solution: After 24 hours in water at 28 °C, approximately 80% decomposition was observed (TLC). |
| Optical Rotation | (c = 0.7, methanol on a dried basis) [a]24 D = -31.5 ± 2° |
COMPUTED DESCRIPTORS
| Molecular Weight | 341.7 g/mol |
|---|---|
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 8 |
| Exact Mass | 340.051211 g/mol |
| Monoisotopic Mass | 340.051211 g/mol |
| Topological Polar Surface Area | 66.6 Ų |
| Heavy Atom Count | 20 |
| Formal Charge | 0 |
| Complexity | 265 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 2 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Melphalan Hydrochloride is a bifunctional alkylating agent and phenylalanine derivative of nitrogen mustard. Melphalan hydrochloride is converted into highly reactive ethylenimmonium intermediates that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine N3 of DNA. This agent also alkylates RNA and protein structures. As a result RNA transcription and protein synthesis are inhibited, ultimately leading to cell growth arrest and/or death.