2259-96-3
Product Name:
CYCLOTHIAZIDE
Formula:
C14H16ClN3O4S2
Synonyms:
6-Chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2-4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Color/Form | CRYSTALS FROM DILUTE ALCOHOL |
| Odor | PRACTICALLY ODORLESS |
| Melting Point | 229-230 |
| Solubility | FREELY SOL IN ACETONE, ETHYL ACETATE, METHANOL; SPARINGLY SOL IN ALC; PRACTICALLY INSOL IN WATER; PRACTICALLY INSOL IN CHLOROFORM, ETHER |
| LogP | 1.95 |
| Stability/Shelf Life | TABLETS, EXPIRATION DATE OF 5 YR |
| Dissociation Constants | PKA: 10.7 IN WATER |
COMPUTED DESCRIPTORS
| Molecular Weight | 389.9 g/mol |
|---|---|
| XLogP3 | 2 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 2 |
| Exact Mass | 389.0270760 g/mol |
| Monoisotopic Mass | 389.0270760 g/mol |
| Topological Polar Surface Area | 135 Ų |
| Heavy Atom Count | 24 |
| Formal Charge | 0 |
| Complexity | 758 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 4 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Cyclothiazide is 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted at positions 3, 5 and 6 by a 2-norbornen-5-yl group, chlorine, and a sulfonamide group, respectively. A thiazide diuretic, it has been used in the management of hypertension and oedema. It has a role as a diuretic and an antihypertensive agent.