210344-95-9
Product Name:
Z-DEVD-FMK
Formula:
C30H41FN4O12
Synonyms:
Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem;Z-D(OMe)E(Ome)VD(OMe)-FMK
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COMPUTED DESCRIPTORS
| Molecular Weight | 668.7 g/mol |
|---|---|
| XLogP3 | 0.9 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 13 |
| Rotatable Bond Count | 23 |
| Exact Mass | 668.27050092 g/mol |
| Monoisotopic Mass | 668.27050092 g/mol |
| Topological Polar Surface Area | 222 Ų |
| Heavy Atom Count | 47 |
| Formal Charge | 0 |
| Complexity | 1110 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 4 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Z-DEVD-FMK is a tetrapeptide consisting of Fmoc-L-aspartic acid 4-methyl ester, methyl L-alpha-glutamic acid 5-methyl ester, L-valine and the fluoromethyl ketone derived from the 1-carboxy group of L-aspartic acid 4-methyl ester coupled in sequence. It is a specific, irreversible caspase-3 inhibitor that also shows potent inhibition of caspase-6, caspase-7, caspase-8, and caspase-10. It has a role as an apoptosis inhibitor, an EC 3.4.22.56 (caspase-3) inhibitor and a neuroprotective agent.