COMPUTED DESCRIPTORS
| Molecular Weight | 6058 g/mol |
|---|---|
| Hydrogen Bond Donor Count | 24 |
| Hydrogen Bond Acceptor Count | 124 |
| Rotatable Bond Count | 104 |
| Exact Mass | 6055.2327217 g/mol |
| Monoisotopic Mass | 6054.2293668 g/mol |
| Topological Polar Surface Area | 2570 Ų |
| Heavy Atom Count | 376 |
| Formal Charge | 0 |
| Complexity | 16500 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 54 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 18 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Oblimersen is a phosphorothioate antisense oligonucleotide. Targeted to the initiation codon region of the bcl-2 mRNA, oblimersen inhibits bcl-2 mRNA translation, resulting in decreased expression of the bcl-2 protein, an apoptotic inhibitor expressed in some types of cancer and linked to tumor drug resistance. This agent may enhance the efficacy of standard cytotoxic chemotherapy. (NCI04)