CHEMICAL AND PHYSICAL PROPERTIES
| Color/Form | Yellow, amorphous solid |
|---|---|
| LogP | log Kow = 2.16 |
| Stability/Shelf Life | STABLE IN AIR & LIGHT. /HCL/ |
| Optical Rotation | Specific optical rotation = +214 deg at 25 °C/D (chloroform) |
| Decomposition | When heated to decomposition it emits toxic fumes of /chlorine, oxides of sulfur, and oxides of nitrogen/. |
| Ionization Efficiency | Positive |
| Dissociation Constants | Characteristic taste; odorless or has faint mercaptan-like odor; freely soluble in water, dimethylformamide, methanol; soluble in alcohol; practically insoluble in acetone; pKa: 7.72 in pure water /Clindamycin hydrochloride/ |
| Collision Cross Section | 209.07 Ų [M+Na]+ 202.49 Ų [M+H]+ 204.41 Ų [M-H]- |
| Other Experimental Properties | Mol wt: 479.47. White crystals from ethanol-ethyl acetate, mp 141-143 °C. Specific optical rotation = +144 deg at 25 °C/D (water). pKa 7.6. Soluble in water, pyridine, ethanol, DMF /Clindamycin hydrochloride monohydrate/ |
COMPUTED DESCRIPTORS
| Molecular Weight | 425.0 g/mol |
|---|---|
| XLogP3 | 2.2 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 7 |
| Exact Mass | 424.1798710 g/mol |
| Monoisotopic Mass | 424.1798710 g/mol |
| Topological Polar Surface Area | 128 Ų |
| Heavy Atom Count | 27 |
| Formal Charge | 0 |
| Complexity | 502 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 9 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Clindamycin is an antibacterial prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of certain serious bacterial infections, such as: