CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid; [Merck Index] |
|---|---|
| Color/Form | Crystals |
| Melting Point | MP: 103-105 °C /Monensin monohydrate/ |
| Solubility | Slightly soluble in water |
| Stability/Shelf Life | Stable under recommended storage conditions. /Monensin sodium salt/ |
| Decomposition | When heated to decomposition it emits acrid smoke & irritating fumes. |
| Dissociation Constants | pKa = 6.6 (in 66% N,N-dimethylformamide) |
| Collision Cross Section | 245.1 Ų [M+Na]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards] |
| Other Experimental Properties | Very stable under alkaline conditions. |
| Chemical Classes | Biological Agents -> Bacterial Toxins |
COMPUTED DESCRIPTORS
| Molecular Weight | 670.9 g/mol |
|---|---|
| XLogP3 | 4.2 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 11 |
| Rotatable Bond Count | 10 |
| Exact Mass | 670.42921279 g/mol |
| Monoisotopic Mass | 670.42921279 g/mol |
| Topological Polar Surface Area | 153 Ų |
| Heavy Atom Count | 47 |
| Formal Charge | 0 |
| Complexity | 1110 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 17 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Monensin A is a spiroketal, monensin A is the major component of monensin, a mixture of antibiotic substances produced by Streptomyces cinnamonensis. An antiprotozoal, it is used as the sodium salt as a feed additive for the prevention of coccidiosis in poultry and as a growth promoter in cattle. It has a role as a coccidiostat, an antifungal agent and an ionophore. It is a monocarboxylic acid, a cyclic hemiketal, a spiroketal and a polyether antibiotic.