148-82-3
Product Name:
Melphalan
Formula:
C13H18Cl2N2O2
Synonyms:
L -PAM;L -Phenylalanine mustard;4-[Bis(2-chloroethyl)amino]-L -phenylalanine
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Melphalan appears as white to buff-colored powder. Odorless or with a faint odor. An antineoplastic medicine. |
|---|---|
| Color/Form | Needles from methanol (monosolvate) |
| Odor | Odorless |
| Melting Point | 351 °F (decomposes) (NTP, 1992) |
| Solubility | less than 1 mg/mL at 72 °F (NTP, 1992) |
| LogP | -0.52 |
| Stability/Shelf Life | Stable under recommended storage conditions. |
| Optical Rotation | Specific optical rotation: -31.5 deg at 22 °C/D (c = 0.67 in methanol); +7.5 deg 25 °C/D (c = 1.33 in 1.0 N HCl) |
| Decomposition | Hazardous decomposition products formed under fire conditions - Carbon oxides, nitrogen oxides (NOx), hydrogen chloride gas. |
| Collision Cross Section | 168.7 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards] |
| Other Experimental Properties | Needles from methanol (monosolvate), MP: 1815.-182 °C (decomposes). Specific optical rotation: -7.5 deg at 21 °C/D (c = 1.26 in 1.0 N HCl) /Melphalan D-form/ |
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H300:Acute toxicity,oral H317:Sensitisation, Skin H340:Germ cell mutagenicity H350:Carcinogenicity H361:Reproductive toxicity |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. |
COMPUTED DESCRIPTORS
| Molecular Weight | 305.20 g/mol |
|---|---|
| XLogP3 | -0.5 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 8 |
| Exact Mass | 304.0745332 g/mol |
| Monoisotopic Mass | 304.0745332 g/mol |
| Topological Polar Surface Area | 66.6 Ų |
| Heavy Atom Count | 19 |
| Formal Charge | 0 |
| Complexity | 265 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Melphalan appears as white to buff-colored powder. Odorless or with a faint odor. An antineoplastic medicine.