CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Color/Form | VISCOUS, LIGHT AMBER-COLORED, LIQ, WHICH CRYSTALLIZES ON PROLONGED STANDING INTO LARGE IRREGULAR CRYSTALS |
| Boiling Point | 176 °C @ 0.7 MM HG |
| Solubility | SOL IN WATER, ALC, & ACETONE; INSOL IN ETHER /HCL/ |
| LogP | 5.54 |
| LogS | -5.3 |
| Stability/Shelf Life | SOLN ARE SENSITIVE TO AIR & LIGHT /HYDROCHLORIDE/ |
| Refractive Index | INDEX OF REFRACTION: 1.5780 @ 23 °C/D |
| Kovats Retention Index | 2212 2210 2240 2238 2220 2211 2231 2220.8 2221.1 2239 2235 2275 2232.1 2256.5 |
| Other Experimental Properties | SLIGHT, CHARACTERISTIC ODOR; MELTS BETWEEN 170 & 178 °C /HYDROCHLORIDE/ |
COMPUTED DESCRIPTORS
| Molecular Weight | 352.4 g/mol |
|---|---|
| XLogP3 | 5.2 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 4 |
| Exact Mass | 352.12210427 g/mol |
| Monoisotopic Mass | 352.12210427 g/mol |
| Topological Polar Surface Area | 31.8 Ų |
| Heavy Atom Count | 24 |
| Formal Charge | 0 |
| Complexity | 416 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Triflupromazine is a member of the class of phenothiazines that is 10H-phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(dimethylamino)propyl group at the N-10 position. It has a role as a dopaminergic antagonist, an antiemetic, a first generation antipsychotic and an anticoronaviral agent. It is a tertiary amine, a member of phenothiazines and an organofluorine compound. It derives from a hydride of a 10H-phenothiazine.