COMPUTED DESCRIPTORS
| Molecular Weight | 2330.6 g/mol |
|---|---|
| Hydrogen Bond Donor Count | 12 |
| Hydrogen Bond Acceptor Count | 24 |
| Rotatable Bond Count | 18 |
| Exact Mass | 2329.5323361 g/mol |
| Monoisotopic Mass | 2328.5289813 g/mol |
| Topological Polar Surface Area | 549 Ų |
| Heavy Atom Count | 168 |
| Formal Charge | 0 |
| Complexity | 4360 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 3 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Fimaporfin is a synthetic light-activated compound composed of three benzenesulfonic acid isomers: fimaporfin A (TPCS2a; tetraphenyl chlorin disulfonate), fimaporfin B, and fimaporfin C, with potential photosensitizing activity upon photodynamic therapy (PDT). Upon intradermal administration, fimaporfin is incorporated into the tumor cells' endosome and lysosome membranes. Subsequently, cytotoxic agents are administered and accumulate in the endosomal and lysosomal compartments; upon local activation by light, fimaporfin produces reactive oxygen species (ROS), such as singlet oxygen, damaging endo/lysosomal membranes and accumulated cytotoxic agents are released into the tumor cell cytosol. This photochemical internalization (PCI) method can enhance the efficacy and selectivity of cytotoxic agents.