CHEMICAL AND PHYSICAL PROPERTIES
| Color/Form | Crystals from acetone/hexane |
|---|---|
| Melting Point | 137-145 |
| Solubility | 0.64 g/l |
| LogP | 4.63 |
| Optical Rotation | MW: 360.53. Crystals from hexane, mp 126-130 °C. Specific optical rotation: + 24 deg at 25 °C/D /Propionate/ |
| Other Experimental Properties | White fine powder; practically insoluble in water; freely soluble in methylene chloride and methanol; mw 593.2 /Dronedarone hydrochloride/ |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
COMPUTED DESCRIPTORS
| Molecular Weight | 556.8 g/mol |
|---|---|
| XLogP3 | 7.2 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 18 |
| Exact Mass | 556.29709368 g/mol |
| Monoisotopic Mass | 556.29709368 g/mol |
| Topological Polar Surface Area | 97.2 Ų |
| Heavy Atom Count | 39 |
| Formal Charge | 0 |
| Complexity | 800 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Dronedarone is a member of the class of 1-benzofurans used for the treatment of cardiac arrhythmias. It has a role as an anti-arrhythmia drug, an environmental contaminant and a xenobiotic. It is a member of 1-benzofurans, a tertiary amino compound, a sulfonamide, an aromatic ketone and an aromatic ether.