13523-86-9
Product Name:
Pindolol
Formula:
C14H20N2O2
Synonyms:
1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol;1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol;Pindolol
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CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Color/Form | Crystals from ethanol |
| Odor | Faint odor |
| Melting Point | 171 °C |
| Solubility | >37.2 [ug/mL] (The mean of the results at pH 7.4) |
| LogP | 1.75 |
| Decomposition | When heated to decomposition it emits toxic fumes of /nitrogen oxides/. |
| Caco2 Permeability | -4.78 |
| Dissociation Constants | 9.54 |
| Collision Cross Section | 159.1 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)] |
| Kovats Retention Index | 2268 2273 2231 2260 2261 |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
COMPUTED DESCRIPTORS
| Molecular Weight | 248.32 g/mol |
|---|---|
| XLogP3 | 1.8 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 6 |
| Exact Mass | 248.152477885 g/mol |
| Monoisotopic Mass | 248.152477885 g/mol |
| Topological Polar Surface Area | 57.3 Ų |
| Heavy Atom Count | 18 |
| Formal Charge | 0 |
| Complexity | 248 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Pindolol is a member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol. It has a role as a serotonergic antagonist, a beta-adrenergic antagonist, an antihypertensive agent, a vasodilator agent and an antiglaucoma drug. It is a member of indoles and a secondary amine.