124-87-8
Product Name:
PICROTOXIN
Formula:
C30H34O13
Synonyms:
Cocculin;Picrotoxin, Anamirta cocculin - CAS 124-87-8 - Calbiochem
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Cocculus appears as a poisonous berry, the dried fruit of Anamirta cocculus L. Contains several substances including about one percent picrotoxin. Pure picrotoxin occurs as shiny leaflets with an intensely bitter taste or as a microcrystalline powder. Very poisonous!. Used in medicine as a central nervous system stimulant and antidote for barbiturate poisoning. Not currently regarded as a useful therapeutic agent. |
|---|---|
| Color/Form | Shiny rhomboid leaflets |
| Odor | Odorless |
| Taste | Very bitter |
| Melting Point | 397 °F (EPA, 1998) |
| Solubility | 4100 mg/L |
| LogP | -2.229 |
| Stability/Shelf Life | Stable in air; affected by light |
| Optical Rotation | Specific rotation: -29.3 deg @ 16 °C/d (absolute ethanol, c= 4) |
| Decomposition | When heated to decomposition it emits acrid smoke and fumes |
| pH | A saturated solution in water is neutral to litmus |
| Other Experimental Properties | Picrotoxin is a nonnitrogenous neutral cmpd that can be broken down into two dilactones, picrotoxinin and picrotin; the latter is inactive |
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H300:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P405:Store locked up. P501:Dispose of contents/container to..… |
COMPUTED DESCRIPTORS
| Molecular Weight | 602.6 g/mol |
|---|---|
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 13 |
| Rotatable Bond Count | 2 |
| Exact Mass | 602.19994113 g/mol |
| Monoisotopic Mass | 602.19994113 g/mol |
| Topological Polar Surface Area | 191 Ų |
| Heavy Atom Count | 43 |
| Formal Charge | 0 |
| Complexity | 1290 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 11 |
| Undefined Atom Stereocenter Count | 5 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 2 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Cocculus appears as a poisonous berry, the dried fruit of Anamirta cocculus L. Contains several substances including about one percent picrotoxin. Pure picrotoxin occurs as shiny leaflets with an intensely bitter taste or as a microcrystalline powder. Very poisonous!. Used in medicine as a central nervous system stimulant and antidote for barbiturate poisoning. Not currently regarded as a useful therapeutic agent.