CHEMICAL AND PHYSICAL PROPERTIES
| Boiling Point | 653.7 |
|---|---|
| Solubility | very slightly soluble at pH 1 |
| LogP | 2.9 |
| Dissociation Constants | -1.5 |
COMPUTED DESCRIPTORS
| Molecular Weight | 519.6 g/mol |
|---|---|
| XLogP3 | 4.8 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 11 |
| Rotatable Bond Count | 6 |
| Exact Mass | 519.10105173 g/mol |
| Monoisotopic Mass | 519.10105173 g/mol |
| Topological Polar Surface Area | 148 Ų |
| Heavy Atom Count | 35 |
| Formal Charge | 0 |
| Complexity | 817 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Dabrafenib is an organofluorine compound and antineoplastic agent, used as its mesylate salt in treatment of metastatic melanoma. It has a role as an antineoplastic agent, a B-Raf inhibitor and an anticoronaviral agent. It is a sulfonamide, an organofluorine compound, a member of 1,3-thiazoles and an aminopyrimidine.