CHEMICAL AND PHYSICAL PROPERTIES
| Color/Form | Colorless liquid /sterile injection/ |
|---|---|
| Stability/Shelf Life | Epoetin alfa injection also should not be shaken, since denaturation of the protein with resultant loss of biologic activity may occur; however, a small amount of flocculation in solution reportedly does not affect potency. |
COMPUTED DESCRIPTORS
| Molecular Weight | 848.0 g/mol |
|---|---|
| XLogP3 | 0.8 |
| Hydrogen Bond Donor Count | 7 |
| Hydrogen Bond Acceptor Count | 17 |
| Rotatable Bond Count | 10 |
| Exact Mass | 847.49293524 g/mol |
| Monoisotopic Mass | 847.49293524 g/mol |
| Topological Polar Surface Area | 236 Ų |
| Heavy Atom Count | 59 |
| Formal Charge | 0 |
| Complexity | 1370 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 20 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 2 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Epoetin Alfa is a recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine human erythropoietin (EPO). Produced primarily by cells of the peritubular capillary endothelium of the kidney in response to hypoxia, circulating EPO binds to EPO receptors on the surface of committed erythroid progenitors in the bone marrow resulting in their replication and maturation into functional erythrocytes.