Hederacolchiside A1
| Price | USD9.80 |
| Packge | 1KG |
- Min. Order:1KG
- Supply Ability:20 tons
- Time:2020-02-07
Product Details
- Product NameHederacolchiside A1
- CAS No.106577-39-3
- MFC47H76O16
- MW897.1
- AppearanceSolidWhite to off-white
- density 1.36±0.1 g/cm3 (20 ºC 760 Torr)
- Melting point 253-255℃ (methanol , water )
- Boiling point 967.2±65.0 °C(Predicted)
- storage temp. 4°C, protect from light
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[Product Specification】
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Name
Hederacolchiside A1
Synonym
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Description
Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway[1]. Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro[2].
Related Catalog
Target
PI3K
Akt
mTOR
In Vitro
Hederacolchiside A1 reduces the mitochondrial membrane potential and Bcl-2 protein levels, whereas cleaved caspase-3 was higher[1]. Hederacolchiside A1 effectively inhibits the phosphorylations of phosphatidylinositol 3 kinase (PI3K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR) [1].
In Vivo
hederacolchiside A1 (3.0, 4.5, and 6.0 mg/kg, ip) can significantly inhibit the weight of tumor in an H22 xenograft model[1]. Hederacolchiside A1 (3.25, 7.5, and 15.0 mg/kg, ig) can significantly inhibit the weight of tumor in nude mice xenograft tumor models using human breast carcinoma MCF-7 cells[1].
References
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Density
1.36±0.1 g/cm3 (20 ºC 760 Torr)
Boiling Point
967.2±65.0 °C at 760 mmHg
Melting Point
253-255℃ (methanol , water )
Molecular Formula
C47H76O16
Molecular Weight
897.097
Flash Point
276.2±27.8 °C
Exact Mass
896.513306
LogP
7.36
Vapour Pressure
0.0±0.6 mmHg at 25°C
Index of Refraction
1.610
Water Solubility
Insuluble (3.9E-4 g/L) (25 ºC)
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
- Since:2014-12-17
- Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
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