Dihydrochelerythrine
Product Details
- Product NameDihydrochelerythrine
- CAS No.6880-91-7
- EINECS No.200-258-5
- MFC21H19NO4
- MW349.38
- AppearancePowderWhite to off-white
- Melting point 164-165 °C
- Boiling point 565.9±50.0 °C(Predicted)
- density 1.291±0.06 g/cm3(Predicted)
- storage temp. 2-8°C
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Common Name
Dihydrochelerythrine
Density
1.3±0.1 g/cm3
Boiling Point
565.9±50.0 °C at 760 mmHg
Molecular Formula
C21H19NO4
Melting Point
N/A
MSDS
N/A
Flash Point
171.6±27.3 °C
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Use of Dihydrochelerythrine
Dihydrochelerythrine is a natural compound isolated from the leaves of Macleaya microcarpa; has antifungal activity.IC50 value:Target: in vitro: Dihydrochelerythrine showed the highest antifungal activity against B. cinerea Pers, with 98.32% mycelial growth inhibition at 50 μg/mL. Dihydrochelerythrine inhibited spore germination in vitro in a concentration-dependent manner [1]. Dihydrochelerythrine appeared to be less cytotoxic since the viability of cells exposed to 20 microM dihydrochelerythrine for 24h was reduced only to 53%. A dose-dependent induction of apoptosis and necrosis by chelerythrine and dihydrochelerythrine was confirmed by annexin V/propidium iodide dual staining flow cytometry [2]. Dihydrochelerythrine (4) exhibited strong activity against methicillin-resistant Staphylococcus aureus SK1 and moderate activity against Escherichia coli TISTR 780 with MIC values of 8 and 16 μg/mL, respectively [3].
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Name
1,2-dimethoxy-12-methyl-13H-[1,3]benzodioxolo[5,6-c]phenanthridine
Synonym
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Description
Dihydrochelerythrine is a natural compound isolated from the leaves of Macleaya microcarpa; has antifungal activity.IC50 value:Target: in vitro: Dihydrochelerythrine showed the highest antifungal activity against B. cinerea Pers, with 98.32% mycelial growth inhibition at 50 μg/mL. Dihydrochelerythrine inhibited spore germination in vitro in a concentration-dependent manner [1]. Dihydrochelerythrine appeared to be less cytotoxic since the viability of cells exposed to 20 microM dihydrochelerythrine for 24h was reduced only to 53%. A dose-dependent induction of apoptosis and necrosis by chelerythrine and dihydrochelerythrine was confirmed by annexin V/propidium iodide dual staining flow cytometry [2]. Dihydrochelerythrine (4) exhibited strong activity against methicillin-resistant Staphylococcus aureus SK1 and moderate activity against Escherichia coli TISTR 780 with MIC values of 8 and 16 μg/mL, respectively [3].
Related Catalog
References
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Density
1.3±0.1 g/cm3
Boiling Point
565.9±50.0 °C at 760 mmHg
Molecular Formula
C21H19NO4
Molecular Weight
349.380
Flash Point
171.6±27.3 °C
Exact Mass
349.131409
PSA
40.16000
LogP
4.56
Vapour Pressure
0.0±1.5 mmHg at 25°C
Index of Refraction
1.657
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
- Since:2014-12-17
- Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
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