Nebivolol hydrochloride
Product Details
- Product Name Nebivolol hydrochloride
- CAS No. 152520-56-4
- EINECS No.200-258-5
- MFC22H26ClF2NO4
- MW441.9
- Appearancepowderwhite to off-white
- Melting point 220-222°C
- storage temp. room temp
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Nebivolol hydrochloride Basic information
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Product Name:
Synonyms:
a,a’-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol];(aR,a,2R,2)-rel-a,a[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol];alpha,alpha'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride;D06622;Nebivolol hydrochloride (usan);(±)-[2R*(1S*5S*(S*))]-α,α'-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol);Narbivolol;rel-(aR,a′R,2R,2′S)-a,a′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride
CAS:
MF:
C22H26ClF2NO4
MW:
441.8959464
EINECS:
1806241-263-5
Product Categories:
Mol File:
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Nebivolol hydrochloride Chemical Properties
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Melting point
220-222°C
storage temp.
Desiccate at RT
solubility
DMSO: ≥20mg/mL
form
powder
color
white to off-white
Merck
14,6432
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Safety Information
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Nebivolol hydrochloride Usage And Synthesis
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Chemical Properties
White to Off-White Powder
Uses
A ?-Adrenergic blocker. Used as an antihypertensive
Uses
Nebivolol selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM
Biological Activity
Highly selective β 1 -adrenoceptor antagonist (K i values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at β 1 , 5-HT 1A , β 2 , 5-HT 2 , α 1 , H 1 and D 2 receptors respectively). Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC 50 = 11.36 μ M in renal arteries) and displays antihypertensive activity in vivo .
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
Recommended supplier
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VIP3年
- GLP Pharma Standards
- 152520-56-4 NLT 95%
- Inquiry
- 2026-02-03
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VIP0年
- GLP Pharma Standards
- 152520-56-4 NLT 95%
- Inquiry
- 2026-02-03
- Since:2014-12-17
- Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
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