SALUBRINAL
| Price | USD1.00 |
| Packge | 1KG |
- Min. Order:1KG
- Supply Ability:100kgs
- Time:2019-12-20
Product Details
- Product NameSALUBRINAL
- CAS No.405060-95-9
- MFC21H17Cl3N4OS
- MW479.81
- Appearancepowder, white to light yellow to light gray
- storage temp. -20°C
- Water Solubility Insoluble in water.
- density 1.474±0.06 g/cm3(Predicted)
- Melting point >160°C (dec.)
Mary 0010
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Product Name:
Synonyms:
(2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide;2-Propenamide, 3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-, (2E)-;(2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide Salubrinal;Salubrinal (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide;(E)-3-phenyl-N-[2,2,2-trichloro-1-(quinolin-8-ylcarbamothioylamino)ethyl]prop-2-enamide;N-(2,2,2-Trichloro-1-(3-(quinolin-8-yl)thioureido)ethyl)cinnAmamide;3-PHENYL-N-[2,2,2-TRICHLORO-1-[[(8-QUINOLINYLAMINO)THIOXOMETHYL]AMINO]ETHYL]-2-PROPENAMIDE;(E)-1-(quinolin-8-yl)-3-(2,2,2-trichloro-1-cinnamamidoethyl)thiourea
CAS:
MF:
C21H17Cl3N4OS
MW:
479.81
EINECS:
Product Categories:
Mol File:
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SALUBRINAL Chemical Properties
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density
1.474±0.06 g/cm3(Predicted)
storage temp.
Store at +4°C
solubility
DMSO: soluble20mg/mL, clear
form
powder
pka
10.70±0.70(Predicted)
color
, white to light yellow to light gray
Water Solubility
Insoluble in water.
Sensitive
Light Sensitive
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Safety Information
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SALUBRINAL Usage And Synthesis
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Selective eukaryotic translation initiation factor 2 subunit α (elF2α) dephosphorylation inhibitor. Salubrinal is a selective Inhibitor of eIF2α (eukaryotic translation initiation factor 2 α-subunit) dephosphorylation, and is primarily used experimentally, to study stress responses in eukaryotic cells associated with the action of eIF2. Salubrinal indirectly inhibits eIF2 as a result of reduced dephosphorylation of its α-subunit resulting in activation of stress response pathways usually triggered by events such as oxidative stress or buildup of unfolded protein in the endoplasmic reticulum. Salubrinal can protect PC12 cells from endoplasmic reticulum stress-mediated apoptosis (EC50 = 15 μM) and prevent replication of herpes virus (IC50 = 3 μM), by inhibiting dephosphorylation of eIF2α. As eIF2α has a role in bone formation, salubrinal is also being studied for its effects in osteoporosis. Besides, it also shows potential neuroprotective actions. Although salubrinal has putative therapeutic value due to its function, it is as yet only used experimentally.
1. https://en.wikipedia.org/wiki/Salubrinal
2. http://www.sigmaaldrich.com/catalog/product/sigma/sml0951?lang=en®ion=CA
3. https://www.tocris.com/dispprod.php?ItemId=143907#.WQfadeyECP0
4. http://www.selleckchem.com/products/salubrinal.html
5. https://www.caymanchem.com/product/14735
6. https://www.hellobio.com/salubrinal.html
2. http://www.sigmaaldrich.com/catalog/product/sigma/sml0951?lang=en®ion=CA
3. https://www.tocris.com/dispprod.php?ItemId=143907#.WQfadeyECP0
4. http://www.selleckchem.com/products/salubrinal.html
5. https://www.caymanchem.com/product/14735
6. https://www.hellobio.com/salubrinal.html
Uses
Salubrinal is an endoplasmic reticulum stress blocker that modulates sleep homeostasis and activation of sleep- and wake-regulatory neurons
Definition
ChEBI: A member of the class of quinolines that is a mixed aminal resulting from the formal condensation oftrichloroacetaldehyde with the amide nitrogen of trans-cinnamamide and the primary amino group of 1-quinolin-8-ylthiourea. It is a selective in ibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha).
Biological Activity
Cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2 α ). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC 50 ~ 15 μ M).
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SALUBRINAL Preparation Products And Raw materials
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
- Since:2014-12-17
- Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
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