Indirubin
| Price | USD2.00 |
| Packge | 1kg |
- Min. Order:1kg
- Supply Ability:100kg
- Time:2019-07-06
Product Details
- Product NameIndirubin
- CAS No.479-41-4
- EINECS No.610-392-0
- MFC16H10N2O2
- MW262.26
- AppearancePurple powder.Very Dark Red
- Melting point 350°C(lit.)
- storage temp. -20°C
- Boiling point 496.6±45.0 °C(Predicted)
- density 1.417±0.06 g/cm3(Predicted)
| Indirubin Basic information |
| Product Name: | Indirubin |
| Synonyms: | [2,3'-Biindolinylidene]-2',3-dione;Indirubin (Synthetic), >=98%;Indirubin/Folium Isatidis Extract;Isoindogotin;(delta(sup2,3’)-biindoline)-2’,3-dione;3-(1,3-dihydro-3-oxo-2h-indol-2-ylidene)-1,3-dihydro-2h-indol-2-on;c.i.73200;2-(2-oxo-1h-indol-3-ylidene)-1h-indol-3-one |
| CAS: | 479-41-4 |
| MF: | C16H10N2O2 |
| MW: | 262.26 |
| EINECS: | 1806241-263-5 |
| Product Categories: | Inhibitors;Active Pharmaceutical Ingredients;Natural Plant Extract |
| Mol File: | 479-41-4.mol |
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| Indirubin Chemical Properties |
| Melting point | 350°C(lit.) |
| λmax | 540nm(DMSO)(lit.) |
| CAS DataBase Reference | 479-41-4(CAS DataBase Reference) |
| Safety Information |
| RTECS | DU2995000 |
| Indirubin Usage And Synthesis |
| Description | Indirubin is the active ingredient of Danggui Longhui Wan, a traditional Chinese medicine containing plants such as Indigofera tinctoria L. and Isatis tinctoria L, which are used in traditional Chinese medicine to treat chronic diseases. Indirubin and its analogues are reported as potent inhibitors of cyclin-dependent kinases (CDKs). This could attribute to the positive effect of indirubin on counteracting proliferative diseases, such as chronic myelocytic leukemia (CML), a slowly progressive disease characterized by the overproduction of granulocytes. |
| References | [1] Tina Bla?evi?, Elke H. Heiss, Atanas G. Atanasov, Johannes M. Breuss, Verena M. Dirsch and Pavel Uhrin, Indirubin and Indirubin Derivatives for Counteracting Proliferative Diseases, Evidence-Based Complementary and Alternative Medicine, 2015, vol. 2015, Article ID 654098 [2] Ralph Hoessel, Sophie Leclerc, Jane A. Endicott, Martin E. M. Nobel, Alison Lawrie, Paul Tunnah, Maryse Leost, Eve Damiens, Dominique Marie, Doris Marko, Ellen Niederberger, Weici Tang, Gerhard Eisenbrand and Laurent Meijer, Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases, Nature Cell Biology, 1999, vol. 1, 60-67 |
| Uses | Indigopurpurin is a purple 3,2-bisindole derivative and was shown to exhibit inhibitory allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model. |
| Uses | An inhibitor of GSK-3β and cyclin-dependent kinases. |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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