Progesterone

Price	USD1.00
Packge	1KG

Product Details

Product NameProgesterone
CAS No.57-83-0
EINECS No.200-350-6
MFC21H30O2
MW314.46
InChIKeyRJKFOVLPORLFTN-LEKSSAKUSA-N
AppearancepowderYellow to yellow-brown
Water Solubility <0.1 g/100 mL at 19 ºC
Melting point 128-132 °C (lit.)
storage temp. room temp
density d23 1.166; d20 1.171
Boiling point 394.13°C (rough estimate)

AD68

Progesterone Basic information

Product Name:	Progesterone
Synonyms:	PROGESTERONE-WATER SOLUBLE;progestin;PROGESTERONE;PRIMOLUT;17alpha-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione;17alpha-Progesterone;3,20-Pregnene-4;4-Pregnen-3,20-dion
CAS:	57-83-0
MF:	C21H30O2
MW:	314.46
EINECS:	200-350-6
Product Categories:	MI;FINISHED MEDICINE;Steroids;ketone;Biochemistry;Steroids (Others);Intermediates & Fine Chemicals;Pharmaceuticals;Intracellular receptor;Steroid and Hormone;API;ENDOMETRIN;Plant extract;Pharma material;Inhibitors
Mol File:	57-83-0.mol

Progesterone Chemical Properties

Melting point	128-132 °C(lit.)
alpha	186 º (c=1, ethanol)
Boiling point	394.13°C (rough estimate)
density	d23 1.166; d20 1.171
refractive index	182 ° (C=2, Dioxane)
Fp	2℃
storage temp.	Store at RT
solubility	H₂O: 25 mg/mL, may be clear to slightly hazy
form	powder
color	Yellow to yellow-brown
Water Solubility	<0.1 g/100 mL at 19 ºC
Merck	7773
Stability:	Stable. Incompatible with strong oxidizing agents.
InChIKey	RJKFOVLPORLFTN-LEKSSAKUSA-N
CAS DataBase Reference	57-83-0(CAS DataBase Reference)
NIST Chemistry Reference	Progesterone(57-83-0)
EPA Substance Registry System	Pregn-4-ene-3,20- dione(57-83-0)

Safety Information

Hazard Codes	Xn,T,F
Risk Statements	40-45-62-36-20/21/22-11
Safety Statements	36/37-45-53-16
RIDADR	UN 1648 3 / PGII
WGK Germany	3
RTECS	TW0175000
HS Code	29372390
Hazardous Substances Data	57-83-0(Hazardous Substances Data)

Progesterone Usage And Synthesis

Description	Progesterone is a hormone released by luteal cells in the ovaries which contains 21 Carbon Atoms. Progesterone is also a crucial metabolic intermediate in the production of other endogenous steroids. There are two crystal forms of progesterone, that are type-α and type-β, the two types have similar physiological activity. Type-α is precipitated from dilute ethanol as orthorhombic white prismatic crystal, while type-β is orthorhombic white needle crystal, they are both insoluble in water, but soluble in ethanol, ethyl ether, chloroform, acetone, dioxane and concentrated sulfuric acid. Progesterone can be released by the ovary, placenta and adrenal cortex. Its physiological function mainly manifests in promoting estrogen treated over thicken lining of the uterus to continue the development, proliferation and thickening and hypertrophy, soften and secretion of mucus in order to make good condition for implantation of the fertilized egg. After the implantation, early stage survival and development of fertilized egg is also under the control of the high progesterone release. As a result, progesterone is a very important hormone in the female reproductive system, and it is also an important intermediate in the biosynthesis of steroid hormones. All steroid hormone releasable glands can produce progesterone, but only ovarian and placenta can release progesterone as the main hormone. Ovarian will release large amount of progesterone in the luteal phase after ovulation by granulose luteal cells, so progesterone is also named as progestin. Progesterone will decrease in result of corpus luteum atrophy. For normal women, placenta will becomes the main organ maintain progesterone after 8 to 9 weeks of pregnancy, accompany with the ovary releasing until the end of pregnancy.
Uses	The main physiological effects of progesterone: 1. Progesterone can maintain the female animal pregnancy, and cause a series of physiological changes, such as inhibition of female estrus. 2. Progesterone has the power to promote the thickening of the lining of the uterus, promote the bending of the gland and to increase secretion function. 3. Progesterone can inhibit the peristalsis of the uterus, and contribute to the cervix contraction, secretion of mucus, etc.. These physiological changes provide suitable environment for the operation, growth and development of early embryos, as well as the continued growth of the fetus. 4. Small amount of progesterone is also used in combination with the hormone estrogen to promote female estrus. The synergy between progesterone and prolactin can promote the development of mammary glands. 5. Progesterone is involved in the feedback regulation of the hypothalamus and anterior pituitary, which makes the balance of the animal reproductive hormones. In vivo, progesterone content of all sorts of livestock follicular phase is below 1 ng/ml, while in bovine corpus luteum period is approximately 4 ng/ml, pregnancy period is about 18 ng/ml. 6. Formerly biochemical study shows that progesterone modulates action as progestogens, clinical for the treatment of habitual abortion, dysmenorrhea, amenorrhea and other symptoms. One of progesterone's most important functions is as hormone drugs, to promote and maintain the uterine changes in the early stage of pregnancy, used in habitual abortion, irregular menstruation, etc.. In addition, progesterone also behaves as steroid hormone drug as well as progestogens, which is used in treatment of threatened abortion.
Preparation	Progesterone can be obtained by oxidation of the pregnenolone. Dry toluene was added to a oven dried reaction kettle, and then cyclohexanone and pregnenolone were added in order with vigorous stirring to dissolve. Side product H2O was removed by Soxhlet extraction with toluene steam, aluminium isopropoxidequickly was added flowingly, the oxidation reaction was hold on at 115 oC for 2h, cooling to 80 oC, add 5% dilute sulfuric acid under stirring then stand by until water and toluene separated, the toluene layer was extracted with water to neutrality and then distillation off toluene and cyclohexanone. Cooling, filtering, filter cake was beated with petroleum, filtering, washing with petroleum, dried as crude progesterone. The crude product was dissolved in ethanol, decolorized by activated carbon, recrystallized to get the final product, yield 80%. Another way to produce progesterone is choosing the 16-Dehydropregnenolone acetate as start material, treated consecutively by catalytic hydrogenation, alkali hydrolysis, oxidation by aluminum isopropoxide, to get the progesterone as final product.
Uses	Sterid hormone produced by the corpus luteum. Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer
Definition	ChEBI: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and ot er species.
Chemical Properties	White powder. Melting point 121°C. Stable in air. Insoluble in water. A female sex hormone. Low toxicity.
Air & Water Reactions	Insoluble in water.
Reactivity Profile	Progesterone is sensitive to light .
Health Hazard	ACUTE/CHRONIC HAZARDS: Progesterone may be absorbed through the skin.
Fire Hazard	Flash point data for Progesterone are not available; however, Progesterone is probably combustible.
Biological Activity	Endogenous progesterone receptor (PR) agonist (EC 50 = 0.5 nM).

Company Profile Introduction

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.

Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.

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Product Details

Company Profile Introduction

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