Lidocaine hydrochloride

Lidocaine hydrochloride Powder CAS 73-78-9 with Best Price

Product discription

Usage And Synthesis

Lidocaine hydrochloride is a class IB antiarrhythmicagent with a different effect on the electrophysiologicalproperties of myocardial cells from that of procainamideand quinidine. It binds with equal affinity to the active (A)and inactive (I) Na+ ion channels. It depresses diastolic depolarizationand automaticity in the Purkinje fiber networkand increases the functional refractory period relative toaction potential duration, as do procainamide and quinidine.It differs from the latter two drugs, however, in that it doesnot decrease, and may even enhance, conduction velocity and increase membrane responsiveness to stimulation.There are fewer data available on the subcellular mechanismsresponsible for the antiarrhythmic actions of lidocainethan on the more established drug quinidine. It has been proposedthat lidocaine has little effect on membrane cation exchangeof the atria. Sodium ion entrance into ventricularcells during excitation is not influenced by lidocaine becauseit does not alter conduction velocity in this area.Lidocaine hydrochloride does depress Na+ influx duringdiastole, as do all other antiarrhythmic drugs, to diminishautomaticity in myocardial tissue. It also alters membraneresponsiveness in Purkinje fibers, allowing increased conductionvelocity and ample membrane potential at the timeof excitation.  

Lidocaine hydrochloride is characterized by strong penetration, strong dispersion, rapidly onset. The anesthetic performance is twice that of procaine and the toxicity is1. There is an anesthetic effect after 5 minutes treatments, and anesthesia can last 1 to 1.5 hours, 50% longer than procaine. The drug is effective on the heart of the disease or arrhythmia caused by cardiac glycoside, but on the supraventricular tachycardia is poor. This product is fast and oral ineffective, with short duration, and often used as intravenous administration.    

Our Service

1.Cooperate with research institutions, we strictly control the process from raw material to finished product.

2.We can provide the reasonable price, high quality products and prompt shipment.

3.We can send the goods to your delivery address directly. It is relatively safe and fast. 

4.Quick and clear response to customers questions, we’ll treat every email and message within 24 hours usually much faster.

5.We can provide you a discount if you place a substantial order with us.

6.Products can be packaged and company logo can be customized according to customer requirements.

Our company

Guangzhou Biocar Biotechnology Co.,Ltd.,formerly known as Guangdong Yangye Pharmaceutical Factory established in 2005, which is affiliated to Wuhan Biocar Group. With the rise of Internet +, company's business process is accelerating. The company's board of directors has decided to establish Guangzhou Yangye Biotechnology Co., Ltd. at the end of 2016.
Guangzhou Biocar Biotechnology Co.,Ltd. is located near Zhujiang New Town, Tianhe District, one of the prosperous areas in Guangzhou. This helps facilitate business negotiations at home and abroad. It is a high-tech enterprise centered in Guangdong, radiating across our country and facing the world. And it is mainly engaged in the research, development and sales of new chemical raw materials, the custom synthesis and import and export of pharmaceutical intermediates and APIs, the agency sales of pharmaceutical chemicals, the research and development, production and sales of flavors, fragrances and chemical raw materials. Its factory covers an area of more than 4,000 acres and has more than 600 employees.
Guangzhou Biocar Biotechnology has a production base for deep processing of feed additives and veterinary drug intermediates based on main pharmaceutical intermediates.
It has always adhered to the tenet of "Being faithful, cultivating harmony and achieving win-win cooperation" and treats every customer sincerely.
We are looking forward to cooperating with you sincerely, and making mutual benefit and brilliance!

Delivery

1. Sent out in 24hours once payment comfirm.
2. Professional agent make sure our ship fastly and safety
3.Offer your tracking number to you once we get it ,in order to facilitateyou track the express

FAQ
Q1: Can i get some samples?
A: Yes, we can supply the sample, but the shipping cost be paid by ourcustomers.
Q2: How to start orders or make payments?
A: Proforma invoice will be sent first after confirmation of order, enclosedour bank information. Payment by T/T, Western Union or Paypal.
Q3: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay theshipping cost or arrange a courier to us and take the samples. You cansend us your product specifications and requests,we will manufacture theproducts according to your requests.
Q4:What's your MOQ?
A:Our MOQ is 1kg. But usually we accept less quantity such as 100g onthe condition that sample charge is 100% paid.
Q5: How about delivery lead time?
A:Delivery lead time: About 3-5 days after payment confirmed. (Chineseholiday not included)
Q6: Do You Ship Over The Weekend?
We use EMS,TNT,FEDEX,DHL four kinds of couriers. EMS don't collected parcelsover the weekend. The packages can be shipped out normally before 12:00a.m in Beijing time if you choose to ship by TNT or FedEx.

Transaction requirements: serious and sincere, pragmatic and efficient
1. We support the verification of the authenticity of our warehouse andproducts through video conversations.
2. If we release this product, it means that we can also produce its similarproducts.
3. We have insured each product, if the goods are lost or damaged, wecan provide a 100% refund.
4. Delivery time limit: 4-7 days in the UK, 10-15 days in other countries.
5. Company qualification: Seven years since its establishment, with 2factories and 8 laboratories,has cooperated with Wuhan Textile Universityand set up a talent reserve base, which can accept the customization ofpharmaceutical intermediates and the mass production of large chemicals.
6. Quality inspection certificate: every product has its third-party qualityinspection certificate to ensure the safety of the product.
7. Advantages: can be customized production, can be shipped in batches,price concessions, high timeliness.
8.Can assist customers in brand design and printing, and has successfullybuilt OMEGA, ZE and other brands
9. Payment method: Western Union, MoneyGram, Bitcoin, bank transfer, remitlyare currently accepted.
10.Reject malicious inquiries, reject scammers
11.Provide door-to-door transportation, as well as normal customs clearanceservices