CAS NO:2227-29-4

Chloro-di(propan-2-yl)silicon CAS NO.2227-29-4

·  Silylates and reduces β-hydroxy ketones selectively

·  Reduces β-hydroxyketones stereoselectively

·  Used in a silylation-reduction-allylation sequence of β-hydroxy esters to homoallylic-substituted 1,3-diols

·  Used in the silylation-hydrosilation-oxidation of allyl alcohols to 1,3-diols

·  Reaction carried out in diastereoselective manner

·  Photochemically removable

·  Reduces β-hydroxy ketones to anti-1,3 diols

·  Used in the tethered reactions of unsaturated alcohols

·  Used in the silicon-based cross-coupling of vinyl ethers with aryl iodides

BOILING POINT: 137°

MOLECULAR WEIGHT: 150.72

SPECIFIC GRAVITY: 0.872

FLASHPOINT: 22°C (72°F)

HMIS KEY: 3-4-1-X

HYDROLYTIC SENSITIVITY: 8: REACTS RAPIDLY WITH MOISTURE, WATER, PROTIC SOLVENTS

FORMULA: C6H15CLSI

REFRACTIVE INDEX: 1.4278

TSCA: TSCA

APPLICATION: REVIEW OF SYNTHETIC UTILITY.1
REDUCES ?-HYDROXYKETONES STEREOSELECTIVELY.2
USED IN THE TETHERED REACTIONS OF UNSATURATED ALCOHOLS.3
USED IN THE SILICON-BASED CROSS-COUPLING OF VINYL ETHERS WITH ARYL IODIDES.4

REFERENCE: 1. HANDBOOK OF REAGENTS FOR ORGANIC SYNTHESIS, REAGENTS FOR SILICON-MEDIATED ORGANIC SYNTHESIS, FUCHS, P. L. ED., JOHN WILEY AND SONS, LTD., 2011, P. 151-156.
2. ANWAR, S. ET AL. CHEM. COMM. 1986, 831.
3. ROBERTSON, J. ET AL. TETRAHEDRON LETT. 1998, 39, 669.
4. EVANS, P. A.; BAUM, E. W. J. AM. CHEM. SOC. 2004, 126, 11150.

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