Product Details
- Product NameU0126
- CAS No.109511-58-2
- MFC18H16N6S2
- MW380.49
- AppearanceWhite solidWhite
- storage temp. Desiccate at +4°C
- density 1.44
- Water Solubility Soluble in DMSO. Poorly soluble in ethanol and water
- Melting point approximate 154℃(dec.)
- Boiling point 565.1±50.0 °C(Predicted)
Heidi 183
| Product Name: |
U0126 |
| Synonyms: |
U0126;1,4-DIAMINO-2,3-DICYANO-1,4-BIS(2-AMINOPHENYLTHIO)BUTADIENE;1,4-DIAMINO-2,3-DICYANO-1,4-BIS(2-AMINOPHYNYLTIO)BUTADIENE;1,4-DIAMINO-2,3-DICYANO-1,4-BIS(O-AMINOPHENYLMERCAPTO)BUTADIENE;1,4-DIAMINO-2,3-DICYANO-1;UO 126;U0126 >99%;2,3-Bis[amino[(2-aminophenyl)thio]methylene]butanedinitrile |
| CAS: |
109511-58-2 |
| MF: |
C18H16N6S2 |
| MW: |
380.49 |
| EINECS: |
|
| Product Categories: |
Signalling;Protein Kinase;Inhibitor |
| Mol File: |
109511-58-2.mol |
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| |
| U0126 Chemical Properties |
| Melting point |
approximate 154℃(dec.) |
| Boiling point |
565.1±50.0 °C(Predicted) |
| density |
1.44 |
| RTECS |
EJ9710000 |
| storage temp. |
Desiccate at +4°C |
| form |
White solid |
| pka |
2.11±0.10(Predicted) |
| Water Solubility |
Soluble in DMSO. Poorly soluble in ethanol and water |
| |
| U0126 Usage And Synthesis |
| Uses |
A chemically synthesized and highly selective inhibitor of both MEK1 and MEK2 with IC50s of 70 nM and 60 nM, respectively. |
| Definition |
ChEBI: A dinitrile that is succinonitrile in which the methylene hydrogens at positions 2 and 3 are substituted by (2-aminophenyl)sulfanyl]methylidene groups. A potent and selective non-competitive inhibitor of MAP kinase kinase. |
| Biological Activity |
Potent and selective non-competitive inhibitor of MAP kinase kinase. Inhibits MEK-1 and MEK-2 (IC 50 values of 0.07 and 0.06 μ M respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4. Centrally active following systemic administration in vivo . Also available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™ . |
Company Profile
Introduction
Technology research and transfer of pilot screening, pilot scale-up and mass production solutions , for pharmaceutical intermediates, biologicals and fine chemicals (Not including inflammable , explosive , hazardous goods ) ; Market : Nano material , metal catalyst , raw material of cosmetics , pharmaceutical intermediates , chemicals , photoelectric material , import and export of technology and goods (For projects subject to approval according to law, business activities can be carried out only after approval by relevant departments ).
