Product Details
- Product NamePasiniazid
- CAS No.2066-89-9
- EINECS No.218-183-2
- MFC13H14N4O4
- MW290.27
- AppearanceneatLight yellow to khaki
- Melting point 142-144°
- storage temp. Keep in dark place,Inert atmosphere,Room temperature
| Pasiniazid Basic information |
| Product Name: |
Pasiniazid |
| Synonyms: |
isonicotinic acid hydrazide 4-aminosalicylate;ISONICOTINIC ACID HYDRAZIDE P-AMINOSALICYLATE SALT;PASINIAZID;isonicotinicacidhydrazidep-*aminosalicylate;PASINIAZIDISONIAZID AMINOSALICYLATE UV;Dipasic;Fintozid;Nidrapas |
| CAS: |
2066-89-9 |
| MF: |
C13H14N4O4 |
| MW: |
290.27 |
| EINECS: |
218-183-2 |
| Product Categories: |
Pharmaceutical Intermediates |
| Mol File: |
2066-89-9.mol |
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| |
| Pasiniazid Chemical Properties |
| Melting point |
142-144° |
| form |
neat |
| |
| Pasiniazid Usage And Synthesis |
| Originator |
Pasinazid, Yick-Vic Chemicals |
| Uses |
antibacterial (tuberculostatic) |
| Manufacturing Process |
10 parts by weight of isonicotinoyl hydrazine was dissolved in 200 by volume of methanol by stirring at 60°C. Then 11.2 parts 4-aminosalycylic acid was added at 60°C. On cooling a salt of both compounds crystallized as yellow prisms with MP: 135°-140°C (decomposed).
Isonicotinic acid hydrazide compound with 4-aminosalicylic acid may be prepared from the same components by using 750 parts of water by volume as a solvent.
10 parts 4-aminosalicylic acid was dissolved in 600 volume parts of water containing 39 parts by volume 2 N ammonium hydroxide. 9 parts by weight isonicotinoyl hydrazide was added and the mixture was heated to 30°C. The solution was acidified with 49 parts by volume of 2 N acetic acid. On cooling isonicotinic acid hydrazide compound with 4-amino-salicylic acid crystallized, which decomposed at 135°-140°C.
The yield was almost quantitative |
| Therapeutic Function |
Antitubercular |
| |
| Pasiniazid Preparation Products And Raw materials |
Company Profile
Introduction
Technology research and transfer of pilot screening, pilot scale-up and mass production solutions , for pharmaceutical intermediates, biologicals and fine chemicals (Not including inflammable , explosive , hazardous goods ) ; Market : Nano material , metal catalyst , raw material of cosmetics , pharmaceutical intermediates , chemicals , photoelectric material , import and export of technology and goods (For projects subject to approval according to law, business activities can be carried out only after approval by relevant departments ).
