CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Color/Form | HEXAKISTETRAHEDRAL CRYSTALS BY SUBLIMATION |
| Melting Point | 180-192 |
| Solubility | 6290 mg/L (freely soluble) |
| LogP | 2.44 |
| Stability/Shelf Life | Stable in light, heat & air /Amantadine hydrochloride/ |
| Dissociation Constants | 10.58 |
| Kovats Retention Index | 1211 1250 1256 1266 1292 1292 1297 1272 1211 1257 |
| Other Experimental Properties | ODORLESS; BITTER TASTE; DOES NOT MELT UP TO 300 °C, BUT SUBLIMES SLOWLY; PKA: 10.36 AT 30 °C; PH (1 IN 5 SOLN) BETWEEN 3.0 & 5.5. WHITE OR NEARLY WHITE CRYSTALLINE POWDER; 1 G IN 2.5 ML WATER, 5.1 ML ALCOHOL, 18 ML CHLOROFORM, 70 ML POLYETHYLENE GLYCOL 400 /AMANTADINE HYDROCHLORDIE/ |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
COMPUTED DESCRIPTORS
| Molecular Weight | 151.25 g/mol |
|---|---|
| XLogP3 | 2.4 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 151.136099547 g/mol |
| Monoisotopic Mass | 151.136099547 g/mol |
| Topological Polar Surface Area | 26 Ų |
| Heavy Atom Count | 11 |
| Formal Charge | 0 |
| Complexity | 144 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Amantadine is a member of the class of adamantanes that is used as an antiviral and antiparkinson drug. It has a role as an antiviral drug, an antiparkinson drug, a dopaminergic agent, an analgesic, a NMDA receptor antagonist and a non-narcotic analgesic. It is a primary aliphatic amine and a member of adamantanes. It is a conjugate base of an adamantan-1-aminium. It derives from a hydride of an adamantane.