30652-11-0
Product Name:
Deferiprone
Formula:
C7H9NO2
Synonyms:
3-Hydroxy-1,2-dimethyl-4(1H)-pyridone;Deferiprone
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CHEMICAL AND PHYSICAL PROPERTIES
| Color/Form | Needles from water |
|---|---|
| Taste | Very bitter taste |
| Melting Point | 272-278 |
| Solubility | Maximum water solubility of 16–18 g/L at 24° |
| LogP | log Kow = -0.77 |
| Stability/Shelf Life | Stable under recommended storage conditions. |
| Dissociation Constants | 3.5 |
| Collision Cross Section | 123.2 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards] |
| Other Experimental Properties | Hydrophilic chelator; forms red colored complexes with iron |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
COMPUTED DESCRIPTORS
| Molecular Weight | 139.15 g/mol |
|---|---|
| XLogP3 | 0.5 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 0 |
| Exact Mass | 139.063328530 g/mol |
| Monoisotopic Mass | 139.063328530 g/mol |
| Topological Polar Surface Area | 40.5 Ų |
| Heavy Atom Count | 10 |
| Formal Charge | 0 |
| Complexity | 228 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Deferiprone is a member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia. It has a role as an iron chelator and a protective agent.