130-26-7
Product Name:
Clioquinol
Formula:
C9H5ClINO
Synonyms:
5-Chloro-7-iodo-8-hydroxyquinoline;5-Chloro-7-iodo-8-quinolinol;5-Chloro-8-hydroxy-7-iodoquinoline;Clioquinol;Iodochlorhydroxyquin
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Iodochlorohydroxyquinoline is a cream-colored to brownish-yellow powder. Practically odorless. Decomposes at 178-179 °C. Used as a topical anti-infective. |
|---|---|
| Color/Form | Brownish-yellow, bulky powder |
| Odor | Practically odorless |
| Melting Point | 352 to 354 °F (NTP, 1992) |
| Solubility | 0.8 [ug/mL] (The mean of the results at pH 7.4) |
| Stability/Shelf Life | Clioquinol darkens on exposure to light. |
| Decomposition | When heated to decomposition it emits very toxic fumes of /hydrogen chloride, hydrogen iodide and nitrogen oxides/. |
| Collision Cross Section | 138.2 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards] |
| Other Experimental Properties | Decompose at about 178-179 °C |
| Chemical Classes | Other Uses -> Pharmaceuticals |
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
COMPUTED DESCRIPTORS
| Molecular Weight | 305.50 g/mol |
|---|---|
| XLogP3 | 3.5 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 0 |
| Exact Mass | 304.91044 g/mol |
| Monoisotopic Mass | 304.91044 g/mol |
| Topological Polar Surface Area | 33.1 Ų |
| Heavy Atom Count | 13 |
| Formal Charge | 0 |
| Complexity | 193 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Iodochlorohydroxyquinoline is a cream-colored to brownish-yellow powder. Practically odorless. Decomposes at 178-179 °C. Used as a topical anti-infective.