Nimesulide
Synonym(s):N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide;Nimesulide
- CAS NO.:51803-78-2
- Empirical Formula: C13H12N2O5S
- Molecular Weight: 308.31
- MDL number: MFCD00079470
- EINECS: 257-431-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-06 18:02:29
What is Nimesulide?
Absorption
Rapidly absorbed following oral administration.
Toxicity
Oral TDLO (human): 1.429 mg/kg; Oral TDLO (woman): 2 mg/kg; Oral LD50 (rat): 200 mg/kg; Oral LD50 (mouse): 392 mg/kg
Description
Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. It is indicated for the treatment of acute pain, symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults. However, due to the risk of causing hepatotoxicity, it should not be taken long-term. It has also been withdrawn from the markets in many countries. It mechanism of action is through targeting on various key mediators in the inflammatory process such as COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.
The Uses of Nimesulide
Labelled Nimesulide . Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-α production.;Labeled Nimesulide, intended for use as an internal standard for th
Background
Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old. Due to concerns about the risk of hepatotoxicity, nimesulide has been withdrawn from market in many countries.
Indications
For the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.
What are the applications of Application
Nimesulide is a selective Cox-2 inhibitor
Pharmacokinetics
Food, gender and advanced age have negligible effects on nimesulide pharmacokinetics.
Metabolism
Hepatic. Extensive biotransformation, mainly to 4-hydroxynimesulide (which also appears to be biologically active).
Properties of Nimesulide
Melting point: | 140-146°C |
Boiling point: | 442.0±55.0 °C(Predicted) |
Density | 1.451±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | Practically insoluble in water, freely soluble in acetone, slightly soluble in anhydrous ethanol. |
form | neat |
color | Light orange to Yellow to Green |
Water Solubility | Soluble in water (<50 µg/ml), 1:10 DMSO:PBS (pH 7.2) (<200 µg/ml), ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml), chloroform, dichloromethane, acetone (freely soluble), and 1N NaOH. |
Safety information for Nimesulide
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral |
Computed Descriptors for Nimesulide
InChIKey | HYWYRSMBCFDLJT-UHFFFAOYSA-N |
Abamectin manufacturer
NB Healthcare Pvt Ltd
AARTIA KEM SCIENCE
Meenaakshi Molecules Pvt Ltd
Globus Pharmachem (Para Products Pvt Ltd)
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