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HomeProduct name listMoxifloxacin hydrochloride

Moxifloxacin hydrochloride

Synonym(s):12-8039;1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydropyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride;Avalox;BAY12-8039;Moxifloxacin hydrochloride

  • CAS NO.:186826-86-8
  • Empirical Formula: C21H25ClFN3O4
  • Molecular Weight: 437.8923032
  • MDL number: MFCD00949117
  • EINECS: 641-756-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-05-18 08:51:57
Moxifloxacin hydrochloride Structural Picture

What is Moxifloxacin hydrochloride?

Description

Moxifioxacin hydrochlodde is one of the two new fluoroquinolonecarboxylic acid antibiotics introduced in 1999 for the treatment of respiratory tract infections such as community-acquired pneumonia, acute exacerbations of bronchitis or acute sinusitis. Moxifloxacin can be synthesized through a 12 step sequence from the classical 4-quinolone-3-carboxylic acid template. Some advantages of Moxifloxacin over Ciprofloxacin, another of Bayer's launched quinolones, have been shown, i.e. an enhanced activity against Gram-positive bacteria (Streptococcus pneumoniae, Clostndium pneumoniae), a favorable pharmacokinetic profile (good tissue penetration and plasma concentrations above MICs) and a lack of phototoxicity (UVA irradiation).

The Uses of Moxifloxacin hydrochloride

Moxifloxacin Hydrochloride is an antibacterial agent that inhibits the activities of Topo II (DNA gyrase) and topoisomerase IV.

Side Effects

The possible serious side effects of moxifloxacin hydrochloride including: unusual bruising/bleeding, signs of a new infection (such as sore throat that doesn't go away, fever), signs of kidney problems (such as change in the amount of urine), signs of liver problems (such as nausea/vomiting that doesn't stop, unusual tiredness, stomach/abdominal pain, yellowing eyes/skin, dark urine).

Precautions

Before taking moxifloxacin hydrochloride, tell your doctor or pharmacist if you are allergic to it; or to other quinolone antibiotics (such as ciprofloxacin, levofloxacin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Properties of Moxifloxacin hydrochloride

Melting point: Slightly yellow to yellow crystalline powder, mp 324-325°
Boiling point: 636℃
Flash point: >110°(230°F)
storage temp.  2-8°C
solubility  H2O: soluble5mg/mL, clear (warmed)
form  powder
color  white to beige
Water Solubility  Sparingly soluble in water. Soluble in DMSO

Safety information for Moxifloxacin hydrochloride

Signal word Warning
Pictogram(s)

Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H319:Serious eye damage/eye irritation
H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Moxifloxacin hydrochloride

InChIKey IDIIJJHBXUESQI-DFIJPDEKSA-N

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