2-Methyl-4-isothiazolin-3-one

Description

Methylisothiazolinone (MI) is an isothiazolinone-derived biocide used for controlling microbial growth in industrial and household products, often in a mixture with 5-chloro-2-methyl-3-isothiazolone (MCI). MI is active against Gram-positive and Gram-negative bacteria, fungi, and yeast with MIC values of 0.0045, 0.0015, >0.01, and 0.0065% (w/w) for S. aureus, P. aeruginosa, A. niger, and C. albicans, respectively, when used alone. MIC values are 7 to 200-fold lower when MI is used in combination with MCI. MI decreases neurite outgrowth of rat cortical neurons when used at concentrations of 0.1-3 μM and inhibits Src family kinases in cell-free assays. MI, alone and as a mixture with MCI, can elicit contact sensitization.

Description

Methylisothiazolinone, along with other isothiazolinones, is a biocide widely used as a preservative in personal care products. It is also used in many industrial processes, such as paint and paper manufacturing, metalworking, mining, and sanitizing.
Because methylisothiazolinone is a strong cytotoxin, its use is under fire because of its dangers to humans and the environment. It is especially problematic when it is added to products such as lotions that remain on the skin.
In recent years, the European Union has begun to crack down on potentially hazardous preservatives in cosmetics. In particular, earlier this year, the?combination of methylisothiazolinone and methylchloroisothiazolinone was restricted, and the use of methylisothiazolinone by itself is scheduled to be banned in 2017.
The EU’s extensive restrictions have severely reduced the number of preservatives allowed for use in personal care products. And bans on animal testing for cosmetics make it unlikely that new biocides will be available in the foreseeable future.

The Uses of 2-Methyl-4-isothiazolin-3-one

Methylisothiazolinone is a preservative compound widely used in cosmetics. It is a contact allergen and sensitiser. Methylisothiazolinone has recently been identified as a neurotoxin that can damage nerve endings with repeated exposure.

What are the applications of Application

2-Methyl-4-isothiazolin-3-one is a potent biocide useful for controlling microbial growth